While induced pluripotent stem cells (iPSCs) have replaced the ethically questionable human embryonic stem cells, iPSC-based neuronal differentiation studies remain descriptive at the cellular level but fail to adequately provide the details that could be derived from a complex, 3D human brain tissue. Brain organoids have emerged as an excellent model for investigating brain development and the mechanisms of related diseases.

Creative Bioarray developed a protocol that is able to differentiate brain organoids from induced Pluripotent Stem Cells(iPSCs). We also provide characterization of iPSC-derived organoids using immunocytochemistry and multi-electrode array (MEA).

iPSC-derived brain organoids can be used for

• Exploring mechanisms for neurological disorders
• Drug screening
• Modeling brain disorders
• Development of organ-chips